Sarah Richardson – Exceptional and unconformable phenomena: Maternal effects and the epistemologies of the life sciences

This talk draws on the intellectual history of maternal effects science to pose the question: What forms of scientific practice and discourse result when life scientists encounter phenomena that persistently rebuff study, control, and optimization, and which demand a high tolerance for uncertainty? The science of maternal effects posits that in addition to transmitting DNA, the maternal body influences descendants’ phenotypes in ways that may constitute a form of heredity. From the earliest days of genetics, scientists struggled to integrate apparent findings of maternal effects into the nuclear genome-centric model of heredity that grounds the modern life sciences. The vexing issues posed by ‘exceptional and unconformable’ findings of maternal effects, however, were not limited to their apparent contradiction with the central dogmas of the genetic sciences. They were also perceived as less ‘knowable’ than the privileged study objects of genetics. Observations falling into the phenomenological category of maternal effects were distinctly out of step with the epistemic styles—the modes of controlling, intervening, explaining, and theorizing—that came to signify good science in the genetic age.

Turtles… dialectics all the way down

“Biology has traditionally defined individuals by the criteria of anatomy (organisms separated from the environment), physiology (organisms whose parts work toward a common end), development (organisms derived from a common precursor cell), genetics (autopoietic organisms whose cells contain the same genome), immunology (organisms that reject non-self), and evolution (that which is selected). Recent studies show that symbiosis, rather than being an exception to the rule, is the rule. A new mode of individuality, the holobiont, has been proposed, consisting of the larger organism and its persistent colonies of symbionts. The holobiont is a multi-lineage organism whose cells function through co-metabolic pathways, whose development integrates the life cycles of several species, and whose phenotype often depends on alleles found in both “host” and symbionts. Natural selection, then, may select for consortia, or teams, of species, and the tree of life may be more like real (i.e., holobiont) trees than we had thought. Birth is more than the generation of a new individual. It also concerns the continuity of the communities. The ramifications of this new view of co-dependent life where “becoming with the other” may be as important as “survival of the fittest” will be examined.”